克罗米酚对男性较高促性腺素性功能减退症有效

纽约（汤姆森社健康版本）1月初四日报道：据发表在12月初出版本的《未婚与生孩子》杂志的一项年度报告宣称作克罗米萘对大部分更高促连续性腺素连续性生活与日俱增的男连续性高血压薄弱。来自曼彻斯特阿拉巴马大学的该年度报告的第一创作者Scott J. Whitten博士在接受汤姆森路透社采访时说道：“继发连续性或获得连续性HH高血压在接受妨碍连续性更大和更昂贵的病人（例如注射促连续性腺激素类）此前顺利进行4个月初的克罗米萘试验连续性病人是薄弱的。”Whitten博士和同事研究成果了克罗米萘对10名HH男连续性高血压（HH是导致男连续性生孩子的相似主因）是否有效。年度报告称作克罗米萘病人1年后，4名卡尔曼(氏)综合征高血压中只有一名高血压的受精卵分子量增加而全垂体功能与日俱增症高血压的受精卵缺乏症状原则上没有得到更佳。只不过，该年度报告宣称作3名男性发病的继发连续性HH男连续性高血压经过3个月初克罗米萘的病人受精卵分子量有了明显增加。近期该组高血压已有两名维持了早产。Whitten博士说道：“除非对克罗米萘病人没有反应，我们不会因为不良反应停止对高血压使用该药物。”再次创作者总结说道：“因为条件有限，对HH高血压促连续性腺激素类药物和克罗米萘的随机研究成果难以顺利进行，然而利用多系列的合理选择标准规范对高血压顺利进行分级显然协助实质性验证克罗米萘维持男连续性更高早产的有效连续性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：白色想象

编辑： 张靖